Transferrin Receptor anticorps

N° du produit ABIN967201

Cet anticorps Souris Monoclonal détecte spécifiquement Transferrin Receptor dans FACS et IHC (fro). Il présente une réactivité envers Humain et a été mentionné dans 2+ publications.

Aperçu rapide pour Transferrin Receptor anticorps (ABIN967201)

Antigène: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Transferrin Receptor est non-conjugé

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: B349(DF1513)

Détail du produit anti-Transferrin Receptor anticorps

Specificité: This antibody reacts with the transferrin receptor, a 180-190 kD transmembrane glycoprotein which exists as a 95 kD homodimer with interchain disulfide bond. The specificity of these antibodies, as demonstrated by immunoprecipitation, are equivalent to OKT9, B3/25 and BerT9.

Purification: Purified.

Immunogène: Cell line KG1.

Isotype: IgG1 kappa

Information d'application

Indications d'application: Immunofluorescense 10-20 micrograms/ml.
Flow cytometry: 1 micrograms/10^6 cells.
Immunohistochemistry: (Acetone-fixed frozen) 5-15 micrograms/mL using avidin-biotin system. This antibody is an indicator of proliferation activity. It also has prognostic significance when typing tumors, such as leukemias and lymphomas.
Staining Procedure: This antibody can be used on frozen tissue sections only in IHC.

Commentaires:

Cellular Localization: Cell membrane.
Recommended Positive Control: Tonsil

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.4 mg/ml.

Buffer: 0.2 mg Immunoglobulin in cell culture supernatant, 50 mM Sodium Borate, 150 mM Sodium Chloride, pH 8.0

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Références pour anticorps anti-Transferrin Receptor (ABIN967201)

Friden, Walus, Musso, Taylor, Malfroy, Starzyk: "Anti-transferrin receptor antibody and antibody-drug conjugates cross the blood-brain barrier." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 11, pp. 4771-5, (1991) (PubMed).

Jing, Spencer, Miller, Hopkins, Trowbridge: "Role of the human transferrin receptor cytoplasmic domain in endocytosis: localization of a specific signal sequence for internalization." dans: The Journal of cell biology, Vol. 110, Issue 2, pp. 283-94, (1990) (PubMed).

Détails sur Transferrin Receptor

Antigène: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Autre désignation: Transferrin Receptor,CD71

Poids moléculaire: ~9095 kDa

ID gène: 7037

Pathways: Transition Metal Ion Homeostasis